National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The development of antibiotic resistance raises an urgent need for new treatment strategies. The purpose of this current investigation was to evaluate the free radicals scavenging ability and the anti-biofilm potent of fractions of ethanol extract from six tropical edible fruits. The capacity of extract to quench free radicals was measured spectrophotometrically by using four antioxidant models. Furthermore, the ability of fruit extract to inhibit Pseudomonas aeruginosa biofilm formation was examined by using the crystal violet assay. Ethyl acetate and methanol fractions of Parkia biglobosa, Zizipus mauritiana, Saba senegalensis and Adansonia digitata showed strong antioxidant activities through their DPPH, ATBS and nitric oxide radicals scavenge abilities as well as their inhibitory potent of deoxyribose degradation. Moreover, fractions of fruit extracts inhibited significantly the P. aeruginosa biofilm formation (up to 72% inhibition) without affect the bacterial growth. Chloroform fraction of Z. mauritiana showed the highest anti-biofilm activity (72.11 ± 0.20% inhibition). In general, chloroform and methanol fractions of fruit extract exhibited more anti-biofilm activity than hexane and ethyl acetate fractions. Tropical edible fruits are potent sources of effective antimicrobial agents. Extensive phytochemical investigation is necessary to isolate the effective antimicrobial drugs for fighting multi-resistant pathogens.
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