International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 7, Issue:9, September, 2018

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(9): 1863-1868

Comparative Study of Serological Test RPR & TPHA for Diagnosis of Syphilis at Tertiary Care Hospital
Arti B. Ninama1 and Mihir R. Dedun2*
1Department of Microbiology, Ananta Institute Medical Sciences & Research Center, Rajsamand, Rajasthan, India
2Department of Community medicine, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
*Corresponding author

Diagnostic and therapeutic approaches in syphilis show wide variation. The use of only one type of serological test is insufficient for diagnosis. To determine diagnostic performance of TPHA (Treponema pallidum Hemagglutination Assay) and RPR (Rapid plasma regain) test for syphilis. A study of syphilis was done over a period of April 2012 to March 2013 at Tertiary Care Hospital, Ahmedabad. A total of 1325 serum samples from clinically suspected cases of syphilis were sent to the microbiology laboratory. Screening test was carried out by RPR test and all positive tests were confirmed by TPHA. From total of 1325 cases, 410 sero positive cases in which285 patients were positive by both RPR and TPHA tests.51 cases (12.4%) which were positive by RPR and Negative by TPHA were later found that they all were false positive due to viral and malarial infection. TPHA is gold standard for the diagnosis of syphilis as compared to RPR/VDRL test. TPHA should be performed along with RPR test as no single serological test can act as the marker of acute infection.

Keywords: Syphilis, TPHA, RPR

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How to cite this article:

Arti B. Ninama and Mihir R. Dedun. 2018. Comparative Study of Serological Test RPR & TPHA for Diagnosis of Syphilis at Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 7(9): 1863-1868. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.