Wnt pathway important in control of the bone formation through the regulation of osteoblast activity, and sclerostin is an important in the regulator of the Wnt pathway by blocking Wnt binding to its receptor and thereby inhibiting bone formation. Blockage of Wnt antagonists such as sclerostin will trigger repair or even healing of bone erosion. Recently show that IL-1Ra has been given important role in therapeutic and pathogenesis of Rheumatoid arthritis (RA). This study planned to evaluate the level of serum sclerostin and level of serum IL-1Ra, in addition to correlate the level of serum sclerostin and IL-1Ra with disease activity by (CDAI or DAS28) in thirty RA Iraqi patients treated with biological therapy (Etanercept). The results show that sclerostin level within normal range in healthy and patients but higher in healthy than patients with biological treatment, also IL-1Ra within normal range in healthy and patients but higher in healthy than patients with biological treatment significant difference (p<0.05).

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