National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Background and Objective: Enteric fever is a global health problem causing high morbidity and mortality, especially in endemic areas such as India. The problem is exacerbated as the causative agent, Salmonella enterica subspecies enterica serovar Typhi (S. typhi), rapidly develops resistance to drugs used in treatment. Factors responsible for emergence of new epidemic strains of Salmonella are not understood, but it is possible that antimicrobial play a role in emergence and persistence of epidemic MDR strains. The MDR S. typhi is on the rise. The object of this study was to determine the susceptibility pattern of various drugs used for treatment of enteric fever. Total of 1020 blood samples obtained from suspected enteric fever patients during June 2015 to July 2016. The sample was processed on Bact/ALERT 3D and isolates obtained from subculture were identified by morphological, biochemical and serological means. Antibiotic susceptibility testing was carried out using modified Kirby–Bauer disk diffusion method. Out of 1020, 26 Salmonella were isolated with isolation rate of 2.55%. 21 were Salmonella typhi and 5 were Salmonella paratyphi A. Susceptibility pattern of S. typhi isolates were 85.71% to ampicillin, 100% to chloramphenicol, 90.48% to co-trimoxazole and 3rd generation cephalosporins, 57.14% to fluoroquinolones. There was higher number of Salmonella enterica serotype typhi isolates resistant to fluoroquinolones (pefloxacin and ciprofloxacin). However chloramphenicol was sensitive to all isolates. This study suggests chloramphenicol as a drug of choice for enteric fever and further monitoring of efficacy of older and newer antibiotics are desirable.
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