National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Myeloid leukemia may be classified as Acute Myeloid Leukemia (AML) or Chronic Myeloid Leukemia (CML) based on its rate of progression. Administration of drugs is the best modality to treat myeloid leukemia, Imatinib mesylate (IM) and cytarabine (cyt) for CML and AML respectively. However, these drugs show severe adverse effects on patients, thereby limiting their therapeutic efficacy. Hence, a safer intervention needs attention. Phytochemicals possess disease fighting properties and hence may be a solution to the problem. Curcumin, a common Indian spice is known to have anti-cancer properties. Present study aims to elucidate the role of curcumin as a chemo-enhancer in myeloid leukemia (CML and AML). Lymphocytes from freshly diagnosed patients (before administration of medication) have been used in this study. Certain proteins contributing to leukemogenesis are being targeted by IM and cyt. Curcumin efficiently modulates these target proteins and maximum effect is seen when drugs are used in conjunction with curcumin, where enhanced induction of apoptosis is facilitated. Curcumin therefore, improved the efficiency of conventional drugs used in myeloid leukemia therapy. This study suggests that curcumin may be used as a combinatorial therapy in leukemia in addition to existing treatment protocols.
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