International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2022 - IJCMAS--ICV 2022: 95.28 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020] For more details click here

Login as a Reviewer

See Guidelines to Authors
Current Issues
Download Publication Certificate

Original Research Articles                      Volume : 7, Issue:4, April, 2018

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(4): 1964-1969

Therapeutic Management of Ivermectin Toxicity in a Calf: A Case Report
Pankaj Kumar Patel1, Sawita Kumari Patel2, Sonam Bhatt1, Desh Deepak1, Arun Prabhakar3, Brijesh Patel3, Chandrama Rabha1 and S.K. Dixit1*
1Division of medicine, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, India
2Division of Veterinary Public Health, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, India
3Division of Livestock Production and Management, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, India
*Corresponding author

A one-month-old, 30 kg calf was presented to Referral Veterinary Polyclinic ICAR-IVRI, Bareilly, with the history of anorexia, salivation, dullness, ataxia, laboured breathing and administration of bolus having a combination of fenbendazole (3000mg) and ivermectin (100mg). Clinical examination revealed pale mucous membrane, mydriasis, the absence of pupillary and menace reflex, sticky salivation, normal body temperature, tachycardia, tachypnoea, dull, depressed, sudden fall with tremors, abnormal posture and gait. Based on the history of overdosing of ivermectin drug and clinical signs presented by the animal the case was diagnosed as ivermectin toxicity. Due to the unavailability of specific antidote (picrotoxin, physostigmine) the case was managed by administration of Activated Charcoal@ 2g/kg BW PO TID, Diazepam@ 0.5 mg/kg bid up to the disappearance of clinical signs. Aggressive fluid therapy was given to the animal for three days. Supportive treatment included inj theophylline @ 6.6mg/kg BW IM, inj Vitamin B- complex with liver extract (3ml IM), inj chlorpheniramine maleate(Avil)@ 0.5mg/kg BW IM daily for five days. The slight improvement was seen in calf after three days and complete recovery after the fifth day of the treatment.

Keywords: Ivermectin toxicity, Salivation, Ataxia, Labored breathing

Download this article as Download

How to cite this article:

Pankaj Kumar Patel, Sawita Kumari Patel, Sonam Bhatt, Desh Deepak, Arun Prabhakar, Brijesh Patel, Chandrama Rabha and Dixit, S.K. 2018. Therapeutic Management of Ivermectin Toxicity in a Calf: A Case Report.Int.J.Curr.Microbiol.App.Sci. 7(4): 1964-1969. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.