A field experiment was conducted during Kharif season of 2008-2009 at the Main Cotton Research Station, Surat, Navsari. The soil of an experimental field was clayey in texture, medium in available nitrogen (297.9 kg ha^-1), medium in available phosphorus (49.19 kg ha^-1) and fairly rich in available potassium (528.5 kg ha^-1) with 7.5 pH. The experiment was conducted in split plot design, comprising three tillage depth in main plot viz. normal tillag eup to7.5 cm (Di), tillage up to 15 cm (D₂) and tillage up to 22.5 cm (D₃) and three irrigation levels in sub plot viz. two irrigations at 25 and 50 days after cessation of rainfall with 80 mm diw at each irrigation (I₂), two irrigations at 25 and 75 days after cessation of rainfall with 60 mm diw at each irrigation (I₂) and three irrigations at 25, 50 and 75 days after cessation of rainfall with 60 mm diw at each irrigation (l₃) were evaluated in split plot design with three replications. The results revealed that seed cotton (3918.90 kg ha^-1) and stalk yields (4119.12 kg ha^-1) The per cent increase in seed cotton yield by the treatment D₃ (tillage upto 22.5 cm) was to the tune of 21.34 and 62.96 per cent over D₂ (tillage upto 15 cm) and D₁ (tillage upto 7.5 cm) treatments, respectively. The treatment l₃ (three irrigations at 25, 50 and 75 days after cessation of rainfall with 60 mm diw at each irrigation) produced significantly the highest seed cotton (3340.31 kg ha^-1) and stalk (3686.86 kg ha^-1) yields. The increase in seed cotton yield due to the treatment I₃ (three irrigations at 25, 50 and 75 days after cessation of rainfall 60 mm diw at each irrigation) was 13.05 per cent higher over I₁ (25 and 50 days after cessation of rainfall with 80 mm diw at each irrigation). The highest nutrient content and uptake by plant was recorded in treatment I₃ (three irrigations at 25, 50 and 75 days after cessation of rainfall with 60 mm diwat each irrigation). On the basis of experimental results, it can be concluded that the highest seed cotton yield and maximum net profit from Kharif cotton Cv. RCH-2 can be obtained by Ploughing the soil upto 22.5 cm depth with application of three irrigations each of 60 mm depth at 25, 50 and 75 days after cessation of rainfall with recommended dose of fertilizer.

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