Considering the cultural contamination problems, an experiment was conducted by using antibiotics (Streptomycin and Gentamycin) for different potato varieties (Kufri Jyoti, Kufri Sadabahar, Kufri Lauvkar and Kufri Sindhuri) at different concentrations to find out contamination free, vigorous in-vitro growth of the potato microplants in MS media. It was observed that lower concentration of Streptomycin (0.1% and 0.2%) can be incorporated in the micropropagation medium of potato to minimize microbial contaminants as well as for improving the vigour of microplantlets, whereas all the concentrations of Gentamycin had negative effect on all the morphological characters studied which needs further investigation with lower concentration. However, all the cultural contamination was completely checked.

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