National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Microbial resistance to antibiotics is a global health problem. Infectious diseases are increasing day by day for various untackable reasons. Thus, there is an urgent need to develop novel antimicrobial agents from natural substances such as plants which are easily available with no toxic effects which are generally associated with synthetic drugs. Besides there is every chance of getting a new drug or lead to drug molecule because of the vast diversity which they possess. The present study was designed to examine synergistic antimicrobial activity of Cinnamon (Cinnamonum verum) oil with some commercial antibiotics and some other essential oils against a panel of multidrug resistant microorganisms. The composition of Cinnamon oil was characterized by GC-MS analysis, the principal compound identified was cinnamaldehyde (62.28%) and benzyl alcohol (24.60%). Combination of Cinnamon oil with antibiotics and other essential oils showed synergistic antimicrobial activity by disc diffusion method. Microbes which showed significant sensitivity were further assayed with various concentrations of the potent combination of Cinnamon oil in a broth dilution method and determined by fractional inhibitory concentration (∑FIC) index. Among the different combinations, Cinnamon oil with ampicillin and Cinnamon oil with Clove oil was found to be most effective combination against pathogenic microorganisms. Synergistic potential of Cinnamon oil can be a new and important way for the treatment of infectious diseases.
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