The aim of this study was to evaluate the incidence of invasive fungal infections (IFIs) in adult and pediatric patients with malignancies, in Assuit governorate, Egypt. This was done by revealing of fungal infection in Blood samples collected from 22 patients with malignancies (from 2-89 years old), from South Egypt Cancer Institute in Upper Egypt, Assiut. Thirty four species invasive fungi belonging to 11 genera were isolated from blood samples on Sabouraoud’s Dextrose Agar (10 genera and 26 species) and Rose Bengal Chloramphenicol Agar (9 genera and 22 species) media. Aspergillus (7 species), Penicillium (11 species), Yeasts (3 species) and Cladosporium (2 species) contributed the broadest spectra of species in all samples tested on two types of media used. Other species were represented by 11 species belonging to 7 genera. A variety of type of filamentous fungi were obtained from hematologic malignancies patients. Further studies are needed to confirm this microbiological trend patients with hematologic malignancies, the results of which might be helpful to improve the management of these patients such as especial care from Clinical, food, drinking and air.

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