International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:5, May, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(5): 474-482

Characterization of Enterococcus faecium CCDM 922 in Respect of its Technological and Probiotic Properties
Ivana Hyrslova1*, Gabriela Krausova1, Jirina Bartova2, Libor Kolesar3, Zoran Jaglic4, Barbora Stankova5 and Ladislav Curda6
1Dairy Research Institute Ltd., Ke Dvoru 12a, 160 00Prague, Czech Republic
2Clinic of Stomatology, General University Hospital and 1stFacultyof Medicine Charles University, Karlovo námÄ›stí 32, 121 11Prague, Czech Republic
3Department of Immunogenetics, Institute for Clinical and Experimental Medicine,Vídeňská 1958/9, 140 21 Prague, Czech Republic
4Veterinary Research Institute, Hudcova 296/70, 621 00 Brno, Czech Republic
54th Department of Internal Medicine, 1st Faculty of Medicine, Charles University,Prague, Czech Republic
6Department of Milk, Fat and Cosmetic, Univesity of Chemical Technology Prague;Technická 5, 166 28Prague, CzechRepublic
*Corresponding author

The aim of this study was to characterize the adherence, immunomodulatory and other health properties and safety of Enterococcus faecium CCDM 922 from the Culture Collection of Dairy Microorganisms Laktoflora®. E. faecium CCDM 922 is susceptible to therapeutically important antibiotics and exhibits good adherence to Caco-2 cells (52.33 ± 10.11 %). Two different concentrations of E. faecium CCDM 922 were used for three and five-day stimulation of human mononuclear cells obtained from peripheral blood. Levels of IFN-γ, IL-6, IL-10, IL-17 and IL-1α were dependent on the density of E. faecium CCDM 922 used for stimulation and on time of stimulation. The cholesterol-lowering effect of E. faecium CCDM 922 was tested in Prague hereditary hypercholesterolemic rats. E. faecium CCDM 922 treatment of male rats reduced LDL- and VLDL-cholesterol levels significantly (P < 0.05). Present results indicated promising probiotic and technological potential for application of E. faecium CCDM 922 in functional foods or dairy products.

Keywords: Enterococcus faecium, immunomodulation, cholesterol, adherence, hydrophobicity

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Ivana Hyrslova, Gabriela Krausova, Jirina Bartova, Libor Kolesar, Zoran Jaglic, Barbora Stankova  and Ladislav Curda. Characterization of Enterococcus faecium CCDM 922 in Respect of its Technological and Probiotic PropertiesInt.J.Curr.Microbiol.App.Sci. 5(5): 474-482. doi:
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