National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The aim of this study was to characterize the adherence, immunomodulatory and other health properties and safety of Enterococcus faecium CCDM 922 from the Culture Collection of Dairy Microorganisms Laktoflora®. E. faecium CCDM 922 is susceptible to therapeutically important antibiotics and exhibits good adherence to Caco-2 cells (52.33 ± 10.11 %). Two different concentrations of E. faecium CCDM 922 were used for three and five-day stimulation of human mononuclear cells obtained from peripheral blood. Levels of IFN-γ, IL-6, IL-10, IL-17 and IL-1α were dependent on the density of E. faecium CCDM 922 used for stimulation and on time of stimulation. The cholesterol-lowering effect of E. faecium CCDM 922 was tested in Prague hereditary hypercholesterolemic rats. E. faecium CCDM 922 treatment of male rats reduced LDL- and VLDL-cholesterol levels significantly (P < 0.05). Present results indicated promising probiotic and technological potential for application of E. faecium CCDM 922 in functional foods or dairy products.
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