National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Diabetes mellitus is a common metabolic disorder of carbohydrate, fat, and protein metabolism. It is characterized by increased glucose levels (hyperglycemia). Diabetes mellitus arises due to defects in insulin secretion or action, or both. Solute carrier family 30 (Zinc transporter) member 8 also known as SLC30A8 is a human gene that codes for a Zinc transporter which in turn is associated to insulin secretion in humans. In pancreatic islets, the production of insulin is linked with the transport of Zinc. This transport is assisted by zinc transporter ZnT- 8 which is a product of the SLC30A8 gene. The function of zinc transporter-8 (ZnT8) is to deliver zinc ion from the cytoplasm into insulin granules. As the insulin granules contain high amounts of zinc, the physiological role of secreted zinc remains elusive. Hence any alteration in the activity of ZnT-8 is expected to be associated with impaired glucose induced insulin response and promote progression from glucose intolerance to diabetes. Recent reports do emerge and confirm a role of SLC30A8 in diabetes. Here we possibly find an emerging role of ZnT-8 in the development of diabetes and discuss potential mechanisms of its involvement in the etiology of both forms of diabetes.
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