National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The effect of fresh juice extract of Azadirachta indica on lipid profile and hepatic function of Plasmodium berghei infected albino mice were investigated. Thirty adult male mice were placed in five groups of six mice each, acclimatized for 7 days and used for the study. Group A was normal control and had free access to feed and water while groups B to E were infected with Plasmodium berghei, and confirmed of parasitamia on the third day. Groups C, D and E were further given standard anti malaria drug (5 mg/kg body weight of Artesunate), 4.3ml/kg and 8.6 ml/kg of fruit juice extract respectively for fourteen days and sacrificed. It was observed that parasitemia caused a marked increase in the activities of liver enzymes and in the levels of total protein, LDL-C and total cholesterol The result revealed that treatment with a standard drug and fruit juice extract significantly reduced (P<0.05) the activities of AST, ALT and ALP. Parasitemia increased the level of total bilirubin significantly (P<0.05) but treatment with standard drug and fruit juice extract lowered the level of the total bilirubin significantly (p˂0.05). Investigation of the effect on lipid profile revealed that the fruit juice extract has cholesterol lowering effect with a significant increase (p˂0.05) in the level of HDL-cholesterol and a significant decrease (p˂0.05) in the level of total cholesterol. However, there was no significant effect (p˃0.05) on the level of triacylglycerol upon treatment with the juice extract. The result has shown that fruit juice extract of Azadirachta indica has hepatoprotective property and lipid lowering (hypolipidemic) effect and may find useful application in the management of hepatic damage, oxidative stress and cardiovascular diseases.
Citations |
 |
 |
 |
 |
