National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The pharmacokinetics and anti-inflammatory activity of andrographolide (50 mg/kg) were studied following intramuscular administration in rats. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC). The mean peak plasma drug concentration of 3.17 ± 0.06 µg/mL was achieved at 4 h. The pharmacokinetic parameters like mean absorption half-life (t½α) (0.61 ± 0.07 h), elimination half-life (t½β) (1.3 ± 0.10 h), apparent volume of distribution (Vdarea) (6.9 ± 0.38 L/kg), area under plasma drug concentration-time curve (AUC0-∞) (13.7 ± 0.47 µg.h/mL), area under first moment curve (AUMC) (61.8 ± 3.44 µg.h2/mL), total body clearance (ClB) (3.6 ± 0.12 L/h/kg) and mean residence time (MRT) (4.6 ± 0.09 h) were observed. Following intramuscular administration of andrographolide, no anti-inflammatory effect was found in rats.
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