National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Rabies is a re-emerging and fatal infectious disease in Asia mainly caused by exposure to rabid dogs. In spite of great advances in virology there is yet no cure for rabies. In recent times newer modality of disease prevention like genetic vaccines and other advanced vaccines have been taken into account. Prevention of dog rabies would be the most effective way to stop rabies transmission to humans. However, vaccinating stray dogs in urban and rural areas using conventional vaccines is always difficult and is not cost-effective for use in most areas. In this study, DNA vaccine encoding the antigenic glycoprotein under the CMV promoter and Kozak sequence was developed and tried in mice by i. m. inoculation. Results showed that 87.5% (7/8) of the immunized mice had developed virus neutralizing antibodies (VNA). The antibody titer after 30 days was 4624. This vaccine afforded 87.5% protection against challenge dose 50 LD50 of CVS-24 after 30 days post challenge. This demonstrated that the DNA vaccine pcDNA-RVG could be administered and it could be effective for the vaccination of dogs to prevent the canine rabies.
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