National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Prolactin, the protein hormone synthesized and secreted predominantly by anterior pituitary gland plays major role in galactopoeisis. The secretion of prolactin is not confined to pituitary alone; there are many immune cells in our body that mediate secretion of prolactin. The prolactin secreted by these immune cells functions as a cytokine that mediate proliferation and maturation of T and B Lymphocytes. Thus prolactin is a dual function protein, as a hormone and as a cytokine. The effect of prolactin over proliferation of T cells has unleashed the possible pathophysiological role of prolactin in several autoimmune disorders. In the present study we compared the level of prolactin in lupus patients with healthy controls. Prolactin levels were significantly elevated in lupus patients compared to healthy controls (P<0.05). This proves the possible pathophysiological role of prolactin in systemic lupus erythematosus. Hence utilization of prolactin antagonists can have significant role in therapy of systemic lupus erythematosus as well as in preventing the complications associated with systemic lupus erythematosus.
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