National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study investigates the green synthesis of phytomagnetic nanocomposites using star anise extract for enhanced anticancer drug delivery. Magnetic iron oxide nanoparticles (Fe₃O₄) were synthesized through an eco-friendly approach in which bioactive phytochemicals present in star anise acted as natural reducing and stabilizing agents. The synthesized nanoparticles were subsequently loaded with 5-Fluorouracil to improve its therapeutic efficacy and minimize systemic side effects. Comprehensive characterization using UV–vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) confirmed the successful synthesis, crystalline nature, surface functionality, and morphology of the nanocomposites. Drug loading efficiency and in vitro release studies demonstrated a controlled and pH-responsive release profile, indicating higher drug release in acidic tumour-like conditions compared to physiological pH. The in vitro anticancer activity was evaluated using standard cell viability assays on selected cancer cell lines. The results revealed that 5-FU-loaded phytomagnetic nanocomposites exhibited significantly enhanced cytotoxic effects compared to the free drug, which may be attributed to improved cellular uptake, sustained drug release, and possible synergistic effects of phytochemicals.
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