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NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here
ICV 2023: 95.56
Index Copernicus ICI Journals Master List 2023 - IJCMAS--ICV 2023: 95.56
For more details click here
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Original Research Articles Volume : 15, Issue : 8, August, 2026

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
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Int.J.Curr.Microbiol.App.Sci.2026.15(8) : 136-143
DOI : https://doi.org/10.20546/ijcmas.2026.1508.014


Epidemiological, Clinical and Therapeutic Profile of Graves' Disease At The National Reference University Hospital of N'Djamena

Daboulaye Allah-Sayim Desire1,7*, Oumar Abba1,7, Batrami Moussa Saleh7, Mouandilmadji Djikoldinguem Marschall1,7, Houba Dallah Tchimby Urbain3,7, Medila Moussa Ali6,7, Bessimbaye Nadlaou4,7, Zakaria Abdel-Madjid Zakaria3,8, Naïbe Dangwe Temoua3,7 and Ali Mahamat Moussa5, 7
1Endocrinology Department of the National University Hospital of Reference (CHU-RN) of N'Djamena, N'Djamena, Chad 
2Intensive Care Unit of the National University Hospital of Reference (CHU-RN) of N'Djamena, N'Djamena, Chad
3Cardiology Department, National University Hospital of Reference (CHU-RN) of N'Djamena, N'Djamena, Chad
4Laboratory Service, National University Hospital of Reference (CHU-RN) of N'Djamena, N'Djamena, Chad
5Hepatology, Department of Gastroenterology and Internal Medicine of the National University Hospital of Reference (CHU- RN) of N’Djamena, N'Djamena, Chad
6Radiology Department, National University Hospital of Reference (CHU-RN) of N'Djamena, N'Djamena, Chad
7Department of Medicine, Faculty of Human Health Sciences (FSSH), University of N'Djamena, N'Djamena, Chad.
8Department of Medicine, Faculty of Health Sciences (FSS), University of Abéché, Abéché, Chad
*Corresponding author
Abstract:

Graves' disease is an autoimmune disorder of the thyroid gland. Its diagnosis is straightforward, based on a clinical triad: thyrotoxicosis, diffuse goiter, and orbitopathy.The objective of our study was to describe the epidemiological, clinical, paraclinical, and therapeutic aspects of Graves' disease. This was a descriptive cross-sectional study conducted over a six-month period, from January 1, 2023, to June 30, 2023, including 45 patients with Graves' disease seen in consultation and/or hospitalized in the Endocrinology Department of the University Hospital of the National Reference Center. Patients underwent an interview, a complete clinical examination, and thyroid function tests, including thyroid ultrasound. The hospitalization rate was 39%. The mean age was 33.6 years, and the female-to-male ratio was 6.5: 1. The main reasons for consultation were palpitations, weight loss, and an anterior cervical mass in 80%, 57.6%, and 44.4% of cases, respectively. TSH levels were low in all patients (100%), and thyroid ultrasound revealed a diffuse and hypervascularized goiter in 72% of cases. First-line treatment included an antithyroid drug (ATD), combined with beta-blockers and anxiolytics. Graves' disease is the most common cause of hyperthyroidism, primarily affecting young women. The clinical presentation typically involves a triad of symptoms: thyrotoxicosis, a diffuse goiter, and orbitopathy. First-line treatment was medical, with thyroidectomy considered in the event of recurrence.


Keywords: Graves' disease, clinical presentation, treatment, Ndjamena

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How to cite this article:

Daboulaye Allah-Sayim Desire, Oumar Abba, Batrami Moussa Saleh, Mouandilmadji Djikoldinguem Marschall, Houba Dallah Tchimby Urbain, Medila Moussa Ali, Bessimbaye Nadlaou, Zakaria Abdel-Madjid Zakaria, Naïbe Dangwe Temoua and Ali Mahamat Moussa. 2026. Epidemiological, Clinical and Therapeutic Profile of Graves' Disease At The National Reference University Hospital of N'Djamena. Int.J.Curr.Microbiol.App.Sci. 15(8): 136-143 doi: https://doi.org/10.20546/ijcmas.2026.1508.014
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