National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Candidiasis are fungal diseases caused by the genera Candida, which are yeasts that preferentially affect the skin and/or mucous membranes such as the mouth, vagina, and digestive tract. These conditions are becoming more and more recurrent due to the general decline in immunity and the emergence of resistance to conventional antifungals. Therefore, fighting against the failures of the treatment of candidiasis, and even better for these diseases, is essential. It is in this context that the present study is situated, which aims to evaluate the anticandidal activity of Ganoderma lucidum extracts (LUGA) on the in vitro growth of clinical strains and a reference strain of Candida in immunocompromised individuals in order to identify the most active extract. To do this, aqueous and hydroalcoholic extracts as well as partitioned extracts were prepared and their anticandidal potencies were tested on four clinical strains of Candida (C. albicans, C. tropicalis, C. glabrata and C. parasislosis) and a reference strain of Candida albicans ATCC 14053. The antifungal tests were carried out by the double dilution method in leaning tubes in solid medium. The results showed no inhibition of germ growth by LUGA aqueous extract; except on Candida albicans ATCC 14053 (reference strain) with a MIC=50 mg/mL. On the other hand, these results showed an inhibition of the growth of germs by the hydroethanolic extract and the acetae-water fraction from this LUGA extract. The minimum inhibitory concentrations (MICs) obtained from this fraction are: MIC (Candida albicans ATCC 14053) = 3.125 mg/mL; MIC (Candida glabrata) = 3.125 mg/mL; MIC (Candida parapsilosis) = 25 mg/mL; MIC (Candida albicans) = 25 mg/mL; MIC (Candida tropicalis) = 50 mg/mL. This study indicates that the acetate-water fraction from LUGA's hydroethanolic extract is the most active on the Candida strains studied among the two extracts evaluated and could constitute a source of effective molecules in the treatment of candidiasis.
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