National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present paper deals with a general biological evaluation on the use of RNA-DNA based sequences as vaccines. This analysis briefly considers the unique properties of RNA and DNA in comparison to those of any other organic molecule so far utilized as drug. After the indicated pre-biotic origin of RNA, proteins and DNA, these biomolecules progressively gave rise to cells and multicellular organisms of various complexity. This evolution occurred by trials and errors and the latter were eliminated. In contrast, human scientific knowledge examines nature empirically and progressively discovers some of its principles and mechanisms. Science investigates complex natural phenomena already established while evolution progressed sequentially from molecules to organism communities. Nucleic acids are different from any type of chemical drugs utilized so far because are the fundamental genetic molecules of life, not alien chemicals as most of previously used drugs. Despite the present deep knowledge on RNA and DNA, many of their effects when injected into complex multicellular organisms are unknown. Manipulations of nucleic acids and their applications to people are experimental and the consequences uncertain. Gene transfer or editing for gene therapies, cure of cancer or other diseases is also experimental but aims to fix human genes. These therapies derive from personal requests with no impositions but accepting possible risks. RNA-DNA-based vaccines instead introduce functional alien viral proteins in the body for immunization but also carrying potential pathological effects. To state that RNA-DNA based vaccines are “safe” is an incorrect scientific statement because of incomplete knowledge of their interactions with our body functions.
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