National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The kidney plays a central role in detoxification and excretion of harmful metabolites and therefore is susceptible to toxicity by xenobiotics. The main goal of this study is to analyze the kidney function status of diabetic Male Wistar albino rat treated with Senna tora extract. Samples of matured and healthy-looking leaves of Senna tora were collected from the school environment, Federal University Wukari, Taraba State, Nigeria. Extraction of the plant was done using absolute ethanol and fractionation with different solvents of varied polarity via separating funnel, starting from ethanol, n-hexane, acetone and lastly, distilled water where four (4) fractions were collected in 100mL beakers each. The animals were treated with the extract Senna tora after they were induced with diabetes using alloxan monohydrate. The animals were kept for about twenty-one (21) days under treatment. After the experimental period, animals were sacrificed under chloroform anesthesia and blood was collected by cardiac puncture and liver was harvested. Determination of serum kidney biochemical parameters were analyzed using various kit of each parameter, such as sodium ions (Na+), potassium ions (K+), chloride ions (Cl-), bicarbonate (HCO3-), urea and creatinine. This study shows that Senna tora have little negative effect on kidney function when used at moderate amounts though the little damage to the kidney have been observed within the limits of experiment, at the concentration dosage of the Senna tora used. There was no level of significance (p≤0.05) in the serum Sodium and Chloride concentration of the results obtained. But the K+ and HCO3?has level of significance (p≤0.05), there was little evidence of kidney damage at high dosages and longer duration of consumption. Conclusion: The finding from this study has suggested the use of S. tora leaf extract in the treatment and management of kidney diseases, though dosage dependent.
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