National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
This study was carried out to evaluate the effect of n-hexane fraction of Senna tora leaves on aspartame-induced toxicity on Wistar albino rats. The study was designed to analyze the lipid profile and determine the antioxidant activities of Senna tora. The study was carried out at Department of Biochemistry’s Laboratory, Federal University, Wukari between September to November, 2022. A total of twenty five (25) adult Wistar albino rats were used for the experiment and were divided into 5 groups (Group 1, 2, 3, 4, 5) with 5 animals in each group. Groups 1 served as a normal control (no treatment) and received only distilled water, Group 2 were induced with aspartame but no treatment was given (negative control), Group 3 were induced with aspartame and treated with 140mg of silymarin drug (positive control), Group 4 and 5 were likewise induced with aspartame but treated with 100 mg/kg and 200 mg/kg of Senna tora leaves respectively, treatment lasted for three weeks. Table 1 contains the results for lipid profile of triglycerides, high density lipoproteins, low density lipoproteins and total cholesterol of n-hexane fraction of Senna tora leaves. There was no significant difference in the levels of High Degree Lipoprotein concentration across the group compared to the normal control (Group 1). An increase in the levels of Low Degree Lipoprotein was observed across the groups compared to the normal control (Group 1). while for total cholesterol, apart from group 5 (Aspartame induced, treated with 200 mg Senna tora extract) all others increased in their level of total cholesterol as compared to the normal control (Group 1) and for triglycerides, a decrease was observed in the levels of triglycerides across the groups as compared to the normal control (Group 1). Results for kidney function tests (KFT) shows increase in the levels of potassium across the groups as compared to the normal control (Group 1). while for levels of bicarbonate a decrease in the level of bicarbonate was observed in group 3 (Induced with aspartame and treated with 140mg of silymarin drug) and 5 (Aspartame induced, treated with 200 mg Senna tora extract) and also an increase in group 2 (Induced with aspartame but no treatment was given) and 4 (Aspartame induced, treated with 100 mg Senna tora extract) was noted. For creatinine and urea levels, an increase was observed across the groups and a normal levels of sodium was seen and also a significant decrease was seen in the levels of chloride. This study suggests that n-hexane fraction of Senna tora leaves have active ingredients that are capable of improving blood lipid profile and this might be useful in the management of cardiovascular diseases.
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