National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Almost all antibiotics target either bacterial function or biofilms but do not consider the damage due to host responses, thus, even if the bacteria are eliminated, the tissue damage cannot be prevented. The mucoid phenotype and oxidative stress severely limit the efficacy of current therapeutics for chronic respiratory infections (CRI) of Pseudomonas aeruginosa in cystic fibrosis (CF) patients. In the present study, we examined the activity of a novel set of VitaminK3 derivatives on biofilms of the mucoid variants of P.aeruginosa. Acyl-homoserine lactones (AHLs) an important signaling molecules in the quorum sensing gene regulatory processes found in numerous gram-negative species of bacteria were evaluated. Further, the radical scavenging ability and antibiofilm activities were studied. The compounds were also screened for cytotoxic activity by the MTT assay on HeLa cell lines. This work highlights the aggravation of the CF lung caused due to biofilm formation, and exacerbation occurring due to oxidative stress, which is a host response. This study thus presents VitaminK3 derivatives as antimicrobial compounds which also prevent oxidative stress and thus serve a dual function. Consequently, further development and use of these compounds is likely to complement current CF therapeutics.
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