National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Dengue fever is a seasonal and emerging acute mosquito-borne arboviral illness affecting tropical and subtropical countries. Prevalence of dengue infection increase in monsoon and post monsoon period. These infections may be asymptomatic or may lead to classical dengue fever (DF), or dengue hemorrhagic fever (DHF) with or without shock. Owing to lack of any diagnostic marker and any specific clinical symptoms to identify cases that will have a severe disease outcome, early diagnosis and close monitoring with symptomatic treatment is necessary. Aims and Objectives: To estimate the prevalence of dengue and to co-relate the serological, clinical, haematological and biochemical data for early diagnosis of severity of dengue infection. Materials and Methods: A cross sectional study was conducted over a period of 6 months from April 2023 to June 2023at ACS Medical College and Hospital, Chennai, a tertiary care center. Serological analysis of 30 dengue IgM antibody positive serum samples by capture ELISA method and correlation between different clinical, serological, hematological and biochemical parameters was done using SPSS software. Results: Out of 30 Dengue IgM positive patients, 26 (86.6%) were males, with mean age group of 15-25 years. 29 (96.6%) patients had fever and 13 (43.3%) had vomiting. 1 patient had co infection with malaria. Thrombocytopenia was observed in 23(76.6%) and leucopoenia in 17 (56.6%) patients. 22 (73.3%) patients had elevated transaminases. Conclusion: This study highlights the importance of clinical history, examination and investigations in timely diagnosis. This along with, helps in early treatment and reduces morbidity & mortality rate.
Anusha Mruthyunjaya Swamy et al., Liver function in dengue and its correlation with disease severity: a retrospective cross-sectional observational study in a tertiary care center in Coastal India. Pan African Medical Journal. 2021;40(261). https://doi.org/10.11604/pamj.2021.40.261.29795
Azin F R, Gonçalves R P, Pitombeira M H, Lima D M, Branco I C. Dengue: profile of hematological and biochemical dynamics. Rev Bras HematolHemoter. 2012;34(1):36-41. https://doi.org/10.5581/1516-8484.20120012. PMID: 23049382; PMCID: PMC3459605.
Banerjee M, Chatterjee T, Choudhary G S, Srinivas V, Kataria V K. Dengue: A Clinicohaematological Profile. Med J Armed Forces India. 2008 Oct;64(4):333-6. https://doi.org/10.1016/S0377-1237(08)80014-7. Epub 2011 Jul 21. PMID: 27688570; PMCID: PMC5035255
Bhatt S, Gething P W, Brady O J, Messina J P, Farlow A W, Moyes C L, Drake J M, Brownstein J S, Hoen A G, Sankoh O, Myers M F, George D B, Jaenisch T, Wint G R, Simmons C P, Scott T W, Farrar J J, Hay S I. The global distribution and burden of dengue. Nature. 2013 Apr 25;496(7446):504-7. https://doi.org/10.1038/nature12060.
Bich Chau T N, Anders K L, Lien L B, Hung N T, Minh HieuL T, et al., (2010) Clinical and Virological Features of Dengue in Vietnamese Infants. PLoSNegl Trop Dis 4(4):e657. https://doi.org/10.1371/journal.pntd.0000657
Chandana Wijesinghe, Afzal A Jabeer, Bushran N Iqbal, Faseeha Noordeen, Relationship between clinical and laboratory features with infecting dengue virus serotypes in a sample of dengue suspected adult patients from 2015-2017 in Sri Lanka,Journal of Clinical Virology Plus,Volume 2, Issue 4,2022,100112,ISSN 2667-0380, https://doi.org/10.1016/j.jcvp.2022.100112
Ding C H, Rashid Z Z, Rahman M M, Khang N F, Low W N, Hussin N, et al., Seroprevalence of acute dengue in a Malaysian tertiary medical centre. Pak J Med Sci. 2016;32(2):495-498. http://dx.doi.org/10.12669/pjms.322.9320
Halsey E S, Marks M A, Gotuzzo E, Fiestas V, Suarez L, et al., (2012) Correlation of Serotype-Specific Dengue Virus Infection with Clinical Manifestations. PLoSNeglTropDis6(5):e1638. https://doi.org/10.1371/journal.pntd.0001638
Karia J, Shah H, Patel P, Bhalodia J, Bhavsar H, Shrimali G, & Patel C. (2011). Evaluation Of Commercial Newer Rapid Test For Detection Of Early Acute Dengue Infection. National Journal of Medical Research, 1(02), 31–33. Retrieved from https://njmr.in/index.php/file/article/view/872
Nandwani S, Bhakhri B K, Singh N, Rai R, Singh D K. Early hematological parameters as predictors for outcomes in children with dengue in northern India: A retrospective analysis. Rev Soc Bras Med Trop. 2021 Jan 29;54:e05192020. https://doi.org/10.1590/0037-8682-0519-2020. PMID: 33533817; PMCID: PMC7849329
Patel M, Patel A, Patel A, Patel S, Padsala S. Study of haematological, biochemical profile and clinical presentation in dengue positive patients: 82 cases. Int J Res Med Sci 2018;6: 2099-2105. http://dx.doi.org/10.18203/2320-6012.ijrms20182296
Rai A, Azad S, Nautiyal S, Acharya S. Correlation between hematological and serological parameters in dengue patients- an analysis of 2022 cases. Trop J Path Micro 2019;5(8):547-554. https://doi.org/10.17511/jopm.2019.i8.07
Shah K, Patel V, Shah N. Seroprevalence of dengue infection in clinically suspected cases of dengue at tertiary care hospital in Gujarat. Int J Med Microbiol Trop Dis 2019;5(3) https://doi.org/10.18231/j.ijmmtd.2019.035
Sharada T, Raghunath P, Suma N. Detection of NS1 antigen, IgM and IgG antibodies using a commercial Dengue rapid test kit for the diagnosis of dengue infection in patients with acute febrile illness. Indian J Microbiol Res 2021;8(3):235-238 https://doi.org/10.18231/j.ijmr.2021.048
Sharma S, Tandel K, Danwe S, Bhatt P, Dash P K, Ranjan P, Rathi K R, Gupta R M, Parida M M. Simultaneous detection and serotyping of dengueinfection using single tube multiplex CDC Dengue Real-Time RT-PCR from India. Virusdisease. 2018 Mar;29(1):40-45. https://doi.org/10.1007/s13337-018-0423-y. Epub 2018 Feb 3. PMID: 29607357; PMCID: PMC5877849.
Trupti Dongre, Pragati Karmarkar. Hematological Parameters and Its Utility in Dengue-A Prospestive Study. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 2 Ver. II (Feb. 2015), PP 31-34. https://doi.org/10.9790/0853-14223134
World Health Organization fact-sheet Dengue and severe dengue https://www.who.int/news-room/fact-sheets/detail/dengue-andsevere-dengue.23April2024
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