National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
This study aimed to determine the prevalence of extended spectrum of beta lactamases (ESBLs), to compare two antibiotic i.e Cefotaxime & Ceftazidime by different phenotypic methods for ESBL con?rmation and to evaluate the antibiotic resistance patterns among ESBL-producing Escherichia coli. Total no. of E.coli isolates were obtained from various clinical samples. They were subjected for the antibiotic susceptibility pattern by Kirby bauer disc diffusion method. 3rd generation cephalosporin resistant isolates were detected for ESBL production. In our isolates we have found increased percentage (100%) isolates showed sensitivity to colistin followed by cefepime which showed sensitivity of (54%). (80 - 90 %) of E.coli isolates showed resistance to cephalosorin group of drugs. (51%) of E.coli isolates were found to be extended spectrum beta lactamase producers using cefotaxime (30µg). Cefotaxme/ Clavulanic acid (30/10 µg) & (55%) os isolates were shown to be positive ESBL using ceftazdime (30 µg), Ceftazidime /Clavulanic acid (30/10 µg). This study found a high rate of ESBL production among cefotaxime antibiotic. Clinical microbiology laboratories should routinely incorporate ESBLdetection methods in their laboratory producers for continous surveillance of drug resistance isolates & antibiogram to guide eprical theapy.
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