National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
A total of 100 clinical samples were collected from microbiology laboratories in and around Chennai, Tamil Nadu, India for screening the Cryptococcus neoformans from patients. Among the 100 clinical samples 48 isolates showed Cryptococcus neoformans growth. The antibiotic sensitivity pattern of Cryptococcus neoformans isolates from the clinical specimens of patients showed highly resistant to antibiotics. The leaves of plant species, Cassia angustifolia, Cassia albus, Cassia wislizenii and Cassia tora were collected and subjected to ethanolic extraction. The ethanolic leaves extracts were tested alone against antibiotic resistant Cryptococcus neoformans isolated from the clinical specimens of patients. Voriconazole has been used as standard antibiotic reference. The antimicrobial activity of individual ethanolic plant extract was higher in Cassia tora than the other extracts tested against antibiotic resistant Cryptococcus neoformans isolated from the clinical samples of patients. Cassia tora extract exhibited inhibition zone of 2.0 and 2.1 cm against clinically isolated antibiotic resistant Cryptococcus neoformans and Standard strains of Cryptococcus neoformans. There is a scope to use ethanolic extracts of the leaves of Cassia tora against antibiotic resistant Cryptococcus neoformans isolated from clinical specimens of patients.
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