An experiment was conducted to study the effect of feeding neem, ginger and garlic powder serum lipid profile and meat cholestrol in Giriraja birds. A total of 150 day old Giriraja birds were procured and allocated to five experimental groups each consisting of three replicates with ten chicks each. Experimental diets for broiler starter and finisher rations were formulated as per the ICAR (2013) standards using commonly available feed ingredients and basal diet (control) T₁ was prepared using corn and soya-bean meal (as per requirement) without supplementation of garlic, neem and ginger for day 1 to 56 days of experimental period and the experimental diets were prepared by incorporating treatment group T₂, T₃, T₄ and T₅ will be included with basal diet+ 0.5 % garlic powder, basal diet + 0.5 % neem powder, basal diet + 1 % ginger and basal diet + 0.5 % garlic powder + 0.5 % neem powder + 1 % ginger powder, respectively. The results revealed that feeding neem, ginger and garlic powder individually and also in combination resulted in no significant improvement on immune response against Newcastle disease. But significant difference was observed in Infectious bursal disease on the 56^th day of the experiment and also showed non-significant (P > 0.05) difference on immune organs weight of birds fed with different treatment groups except bursa which was significant in group fed with 1 % ginger and combination. Significant (P ≤ 0.05) reduction in E. Coli count compared to control group whereas Lactobacillus count was significantly increased in the groups fed with garlic, neem, ginger and combination. However feeding of 1 % ginger and combination have more beneficial effects in Giriraja birds.

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