International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 11, Issue:1, January, 2022

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2022.11(1): 61-77

Isatin: A Short Review of their Antimicrobial Activities
Ashutosh Pathak1,3*iD, P. Malairajan1, Arti Gautam1 and Shibu Das2iD
1Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS), Prayagraj, Uttar Pradesh - 211007, India
2Department of Pharmacy, Maharishi University of Information Technology (MUIT), Lucknow, Uttar Pradesh - 226013, India
3Department of Pharmaceutical Chemistry, Maharana Pratap School of Pharmacy, MohanLal Ganj Lucknow, Uttar Pradesh-226301 India
*Corresponding author

Isatin(2, 3-dioxindate), a particularly effective scaffold with a variety of pharmacological actions, has been developed due to its therapeutic significance in organic and medicinal chemistry. Many researchers have been drawn to this skeleton because of its diverse biological response profile and its multiple possibilities against a variety of activities. Sandmeyer's and Stolle processes are two typical ways for synthesizing isatin derivatives. Many researchers have taken advantage of the isatin moiety by using NH at the first position, C2 and C3 carbonyl positions for the creation of numerous derivatives with varying biological activities. Design strategies for the synthesis of isatin-containing heterocyclics have been discussed in this review paper using several approaches. The chemistry, synthesis, biological and pharmacological action, SAR, and advanced uses of the isatin moiety are all covered in this paper. The progress in the use of isatins for organic synthesis over the previous twenty-five years, as well as a study of their biological and pharmacological properties, are given, together with supplemental data.

Keywords: Isatin, heterocyclic synthesis, analgesic, anti-inflammatory activity, eco-friendly

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How to cite this article:

Ashutosh Pathak, P. Malairajan, Arti Gautam and Shibu Das. 2022. Isatin: A Short Review of their Antimicrobial Activities.Int.J.Curr.Microbiol.App.Sci. 11(1): 61-77. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.