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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(12): 91-110
DOI: https://doi.org/10.20546/ijcmas.2021.1012.011


Anona Genus : Phytochemical, Anticancer and Activity Structure Relationship
Lusi Madona*, Afrizal and Mai Efdi
Universitas Andalas Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Andalas Kampus Limau Manis, Padang, Sumatera Barat, 25163, Indonesia
*Corresponding author
Abstract:

The Annonagenus, consisting of 119 species, has been continuously researched and proven to have various pharmacological activities such as anticancer, antioxidant, anti-inflammatory, antibacterial and so on. Annona plants such as Annona cherimolia Mill, Annona Reticulate, Annona Squamosa, Annona muricata L have antioxidant, antimicrobial, anti-inflammatory, antihelmintic, antipyretic, antihyperglycemic, analgesic, wound healing, and cytotoxic effects caused by the presence of active compounds such as acetogenin, alkaloids. And terpenoids whose role as treatment or prevent anti-cancer. Active compounds in inhibiting or preventing cancer cells are mostly found in the leaves, seeds and fruit of the Annona plant. The anticancer or antitumor activity of bioactive compounds is related to the structure of these compounds. The large number of hydroxyl groups and supported by the hydroxyl position flanking the γ-lactone ring and the stereochemical arrangement of the THF ring determines the effectiveness of cytotoxic activity (the stereochemical arrangement of the THF ACG ring, threo/trans/erythro is more active than threo/trans/threo), the presence of hydroxyl groups at the tail of the ACG carbon chain and for alkaloids in the presence of 1,2-methylenedioxy and methylated nitrogen.


Keywords: Annona, Active Compound, Anti Cancer, Structure-Activity Relationship
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How to cite this article:

Lusi Madona, Afrizal and Mai Efdi. 2021. Anona Genus : Phytochemical, Anticancer and Activity Structure Relationship.Int.J.Curr.Microbiol.App.Sci. 10(12): 91-110. doi: https://doi.org/10.20546/ijcmas.2021.1012.011