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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2021.10(8): 620-628
DOI: https://doi.org/10.20546/ijcmas.2021.1008.072


Pernicious Combination of Covid-19 and Mucormycosis
Vijayalakshmi Nayak1 and R. Shyamala2*
1Department of Dermatology,
2Department of Microbiology, AIIMS Bibinagar, Hyderabad, Telangana, India
*Corresponding author
Abstract:

During the pandemic, the combination of covid 19 with systemic steroids has caused a dramatic increase in the Mucormycosis cases in India. Our narrative review aims to understand the possible pathomechanisms involved in this exponential increase of Mucormycosis cases. The pathogen's virulence depends on the organism's ability to survive in the host by evading the immune system and causing harm to the host cells. Factors involved in the pathogenesis of COVID 19 which might be interested in the pathomechanisms of Mucormycosis are (1) increased expression of GRP 78 receptors (2) alteration of iron metabolism – the role of ferritin and iron (3) hepcidin mimicking activity (4) endothelities (5) damage to beta islet cells of pancreas (6) use of corticosteroid. Heath care-related or nosocomial infection though rare, can not be neglected. Mucormycosis developed in patients with both active SAR-CoV infection and patients who had recovered from COVID19 illness. Mucormycosis involving the nose and sinuses was the most common type. Early diagnosis and treatment of Mucormycosis are essential, as it improves the outcome and decreases the need for surgical intervention hence disfigurement. The combination of COVID 19 infection, steroid use, diabetes, and hospitalisation has caused a surge in Mucormycosis cases in COVID 19 infected patients. Further understanding of the pathogenesis helps in taking measures in the prevention and early management of the infection.


Keywords: Aspergillosis, acute respiratory distress syndrome, pneumonia
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How to cite this article:

Vijayalakshmi Nayak and Shyamala, R. 2021. Pernicious Combination of Covid-19 and Mucormycosis.Int.J.Curr.Microbiol.App.Sci. 10(8): 620-628. doi: https://doi.org/10.20546/ijcmas.2021.1008.072