National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The aim of this study was to investigate the possible protective role of flavonoid quercetin on azithromycin induced toxicity using biochemical and histopathological approaches. In experimental rats oral administration of azithromycin (30 mg/kg b.wt.) for 4 weeks significantly induced liver and renal damage which was evident from the significant (P<0.05) increased levels of liver enzymes (AST and ALT) activities, total bilirubin and creatinine concentration. Moreover, the liver of azithromycin treated rats showed severe sinusoidal hemorrhages, congestion, vacuolar degeneration, fatty changes and disruption of hepatic cords were seen. The lesions in kidneys consisted of severe tubular and cortical hemorrhages, luminal cast formation and desquamous of tubular lining epithelium. Increased space between cardiac muscle fibers, severe hemorrhages and infiltration of inflammatory cells were seen in heart. Quercetin treatment markedly attenuated the azithromycin induced biochemical alterations in serum. Quercetin also ameliorated the azithromycin induced pathological changes when compared with azithromycin alone treated group. These data indicate that the natural dietary antioxidant quercetin had protective effect against azithromycin induced hepatotoxicity and nephrotoxicity in rats.
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