International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 9, Issue:9, September, 2020

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(9): 2926-2934

Protective Effect of Quercetin on Azithromycin Induced Hepatotoxicity and Nephrotoxicityin Wistar Rats
V. Usadadia*, J. M. Patel, P. D. Vihol and A. P. Urkude
Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari-396450, Gujarat, India
*Corresponding author

The aim of this study was to investigate the possible protective role of flavonoid quercetin on azithromycin induced toxicity using biochemical and histopathological approaches. In experimental rats oral administration of azithromycin (30 mg/kg b.wt.) for 4 weeks significantly induced liver and renal damage which was evident from the significant (P<0.05) increased levels of liver enzymes (AST and ALT) activities, total bilirubin and creatinine concentration. Moreover, the liver of azithromycin treated rats showed severe sinusoidal hemorrhages, congestion, vacuolar degeneration, fatty changes and disruption of hepatic cords were seen. The lesions in kidneys consisted of severe tubular and cortical hemorrhages, luminal cast formation and desquamous of tubular lining epithelium. Increased space between cardiac muscle fibers, severe hemorrhages and infiltration of inflammatory cells were seen in heart. Quercetin treatment markedly attenuated the azithromycin induced biochemical alterations in serum. Quercetin also ameliorated the azithromycin induced pathological changes when compared with azithromycin alone treated group. These data indicate that the natural dietary antioxidant quercetin had protective effect against azithromycin induced hepatotoxicity and nephrotoxicity in rats.

Keywords: Azithromycin, Biochemical, Histopathological parameter, Hepatotoxicity, Nephrotoxicity, Quercetin

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How to cite this article:

Usadadia, S. V., J. M. Patel, P. D. Vihol and Urkude, A. P. 2020. Protective Effect of Quercetin on Azithromycin Induced Hepatotoxicity and Nephrotoxicityin Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 9(9): 2926-2934. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.