International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 9, Issue:9, September, 2020

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(9): 911-924

Honey as an Adjuvant Therapy in Acute Potassium Hydroxide Poisoning in Rats
Niveen A. Shehata1*, Doaa M. El-Gharbawy1,Reda H. Elbakary2 and Ahmed A. Hashem1
1Forensic Medicine & Clinical Toxicology, 2Departments, Faculty of Medicine, Tanta University, Egypt
*Corresponding author

Caustic ingestion is a significant medical problem and honey has been used effectively for treatment of different wounds. It was to assess the role of honey as an adjuvant therapy in acute ingestion of potassium hydroxide (KOH) in adult male albino rats. 160 adult male albino rats were randomly divided into 8 groups: gp 1 (-ve control), gp 2 (+ve control), gp 3 (KOH and acetaminophen), gp 4 (KOH and standard treatment), gp 5 (KOH and honey) and gp 6 (KOH and standard treatment plus honey). All groups were subdivided into 2 subgroups according to sacrificing time at the end of 1st week (a) or 3rd week (b). All groups were subjected to macroscopic and histopathological examination of oesophagus and stomach, measuring the mean ulcer index and pH of gastric juice. Macroscopic examination of oesophagus revealed no lesions in all groups. While, gastric mucosa of subgroup 3a was atrophic with small ulcers and haemorrhagic lesions. Subgroup 4b showed nearly healed thick gastric mucosa. Subgroup 5b revealed mild atrophic gastric mucosa, while, significantly healed gastric mucosa was detected in subgroup 6b. These results were confirmed by light microscopic examination of oesophagus and stomach by H&E. Mean pH of gastric juice and mean ulcer index of gastric mucosa/mm2 in subgroups 4b, 5b and 6b were significantly decreased compared to corrosive groups. Using honey as an adjuvant therapy with standard treatment appeared to have a better healing effect in acute potassium hydroxide ingestion.

Keywords: Caustic, Honey, Histopathology, Mean pH and Mean ulcer index

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How to cite this article:

Niveen A. Shehata, Doaa M. El-Gharbawy, Reda H. Elbakary and Ahmed A. Hashem. 2020. Honey as an Adjuvant Therapy in Acute Potassium Hydroxide Poisoning in Rats.Int.J.Curr.Microbiol.App.Sci. 9(9): 911-924. doi:
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