National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Trichinellosis is a parasitic disease causing a harmful inflammatory response. Corticosteroids are used as anti-inflammatory drugs but cause immune-suppression. The present study evaluated the anti-inflammatory effect of resiniferatoxin (RTX), a TRPV1 receptor agonist as an adjuvant therapy with albendazoleon the early and late stages of experimental trichinellosis in comparison with cortisone. The effect of RTX was evaluated by determination of the total larval count in the skeletal muscles, degree of inflammation in intestine and muscles and and the determination of the serum level of interferon gamma (IFN-γ) and inducible nitric oxide synthase (iNOS) by ELISA. Our results showed that treatment with (albendazole and RTX) significantly decreased the total larval count and the inflammation in both the intestinal and the musclar phases in comparison with other groups. In addition, RTX decreased the serum levels of IFN-γ and iNOS. We concluded that RTX has valuable anti-inflammatory and immuno-modulatory effects against T. spiralis infection and is beneficial for the treatment of trichinellosis as compared to cortisone.
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