International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 9, Issue:7, July, 2020

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(7): 3195-3206

Oxidative Stress and Imbalance of Mineral Metabolism Contributes to Clinico-pathobiology of Pediculosis in Dairy Buffaloes
E. Madhesh1*, Umesh Dimri1, Y. Ajith1, S. Shanmuganathan2, P. Sivasankar2 and R. Karthikeyan3
1Division of Medicine,
2Division of Microbiology,
3Division of Biochemistry, Indian Veterinary Research Institute, Izatnagar, UP, 243122, India
*Corresponding author

The present study was aimed to evaluate the mineral metabolism and oxidative patho-biology of lice infestation in buffaloes. Forty-eight buffaloes were divided into four groups; Sucking lice (Hematopinus tuberculatus) infested-mild (Group 1, n=12), moderate (Group 2, n=12), severe (Group 3, n=12) and healthy control (Group 4, n=12). Lice infested animals (Group 1, 2 and 3) animals were treated with a single dose ivermectin subcutaneously at 200 µg/kg body weight and healthy control group were treated with 7 mL of distilled water subcutaneously as placebo therapy. To assess the pathological changes, mineral profile (Iron, Zinc, Copper and Manganese), oxidative stress markers (lipid peroxidation-LPO, reduced glutathione-GSH, superoxide dismutase-SOD, Catalase-CAT and total antioxidant capacity-TAC), Mast cell activity (Histamine, Carboxypeptidase A activity, and Chymase activity), endocrine profile (Cortisol, Total thyroxine-TT4, Total riiodothyronine-TT3, and free triiodothyronine-FT3) and haematological status were evaluated. Significant iron deficiency anemia, lymphocytopenia, neutrophilia, eosinophilia was observed in bubaline pediculosis according to the level of severity of infestation. Remarkably increased oxidative stress and mineral imbalance were observed in sucking lice infested buffaloes. Increased mast cell activity was observed in relation to severity of lice infestation. From the present study, it may be concluded that sucking lice infestation produces significant oxidative stress, mineral imbalance and inflammatory responses in dairy buffaloes. Mast cell may modulate host inflammation via mineralo-oxidative mechanism in sucking lice infestation in buffaloes.

Keywords: Mast cell activity, Bubaline pediculosis, Mineral imbalance, Oxidative stress

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How to cite this article:

Madhesh, E., Umesh Dimri, Y. Ajith, S. Shanmuganathan, P. Sivasankar and Karthikeyan, R. 2020. Oxidative Stress and Imbalance of Mineral Metabolism Contributes to Clinico-pathobiology of Pediculosis in Dairy Buffaloes.Int.J.Curr.Microbiol.App.Sci. 9(7): 3195-3206. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.