National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Blood stream infection is a major cause of morbidity and mortality among neutropenic patients. Despite use of antibiotics and antifungals FN remains a therapeutic challenge. It prolongs hospital stay, increases health-care costs, and compromises chemotherapy efficacy in patients with malignancy who commonly experience neutropenia. This study depicts the microbiological profile, antibiotic sensitivity pattern and relation of BSI and degree of neutropenia in the neutropenic patients. The study was a hospital based prospective observational study conducted in a tertiary care centre in North east, India. Correlation of degree of neutropenia and BSI with analysis of microbiological profile and antibiotic sensitivity pattern of the FN patients admitted from September 2014 to September 2016 was done. A total of 259 cases of fever with neutropenia were included from September 2014 to September 2016 in the present study. Of these, 55 (21.33%) were found to be culture positive. Majority of case 79 (30.5%) were suffering from Acute Myeloid Leukemia (AML). Gram negative bacilli 58.18 % (32) is the most common isolate. The antibiotic sensitivity among GNB was highest for colistin (100%) and teigecycline (93.8%). There is an alarming increase in resistance for cephalosporins and Carbapenems. The frequency of isolation of micro organisms in blood by blood culture in neutropenic patient with fever is 21.23% and Gram negative bacilli is still the predominant pathogens. There is an alarming rise in the resistance against carbapenems and commonly used drugs. It needs to be emphasized that a routine microbiological examination of these group of patients should be carried out routinely and periodically so as to analyse and compare the changing trends in the microbial aetiology and the antibiogram patterns. It is recommended that an effective empirical antibiotic regime could be tailored for this group of patients to decrease the morbidity and mortality.
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