National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Peste-des-petits Ruminants (PPR) is a disease of small ruminants especially goat and its control and eradication till 2030 wants an extensive research to develop a potent vaccine. The role of surface HN protein in the attachment of the virus to cellular receptors makes it an appropriate target to develop a theranostics against the virus. In this study, cytotoxic T cells epitopes that will bind to MHC class I alleles were predicted out using bioinformatic tools. Ten immunogenic peptides were predicted using IEDB web server based on their binding with cow (BoLA) alleles. Among these predicted peptides, five immunogenic epitopes i.e. 429SVFGPLIPHL438, 86HQTKDVLTPL95, 261RDLGLGPPVF270, 432GPLIPHLSGM441 and 555VRLNFKGNPL564 were selected on the basis of their high percentile score. Predicted three dimensional (3D) models of the PPRV HN protein and SLAM receptor were built and used to dock the immunogenic epitopes. It was used to predict the docked site in the structure. Furthermore, the involvement of these predicted epitopes in experiments may lead to creation of novel potent vaccine and diagnostic tools against the PPR.
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