National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Inorganic Arsenic (iAs) contamination of groundwater had been a major health hazard. In West-Bengal, many areas had been found to have high level of iAs in groundwater. Chronic exposure to iAs may lead to the generation of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS). This results in DNA damage, inflammation, impairment of repair activity, thereby culminating in carcinogenesis. Higher telomerase activity may be another manifestation of iAs exposure. This is a pilot study involving 15 subjects residing in an arsenic endemic area of West-Bengal. Accumulation of iAs was tested in the nail, hair and blood samples of these individuals. Extent of ROS, RNS, DNA damage, expression of repair enzymes and status of pro-inflammatory cytokines had been studied. Telomerase activity and NF-κB were also studied. 15 samples were collected from subjects residing in an area having iAs within safe limits. It was observed that in samples from iAs endemic region, ROS and RNS generation was high, followed by DNA damage. These individuals showed higher telomerase activity compared to the control. Status of NF-κB and pro-inflammatory cytokines had been found to be elevated in comparison to the control. Therefore, these parameters could assess the susceptibility of these individuals towards carcinogenesis.
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