National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The incidence of AmpC beta-lactamase producing K. pneumoniae has been steadily increasing over past years and is of significant concern as they restrict therapeutic options and cause treatment failure. The objective of the present study was to know the occurrence of AmpC beta-lactamase producing K. pneumoniae and to create a baseline antibiotic resistance data to implement effective antibiotic policy. A total of 132 non duplicate K. pneumoniae isolates obtained from various clinical samples over a period of 18 months were tested for inducible and plasmid- mediated AmpC beta-lactamases by disc antagonism and AmpC disc test respectively. 11.3% were inducible and 28.7% were plasmid mediated AmpC beta-lactamases producers. Detection of inducible and plasmid mediated Amp C beta-lactamases was higher among outpatient (18.7% and 34.3%) compared to ward isolates (10.3% and 29.3%) and ICU isolates (7.1% and 23.8%). MDRs among inducible and plasmid mediated beta-lactamases were 20% and 44.7% respectively. All the MDRs with Amp C beta - lactamase producers were susceptible to cefipime and imipenem. Association of aminoglycosides and imipenem resistance among Amp C beta-lactamase positive isolates were higher compared to negative isolates ( p value < 0.5) whereas cefoperazone-sulbactam, piperacillin- tazobactam, cefipime, ciprofloxacin and co-trimoxazole resistance did not show significant association (p value > 0.5) among positive and negative isolates. Cefipime and imipenem resistance among cefoxitin resistant isolates was 81.8% and 39.3% respectively. Occurrence of these enzymes associated with antibiotic resistance and the clinical implications should be cautiously considered during the establishment of an antibiotic policy in a hospital setting.
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