Biophysical Characterization of Chemically Synthesized Antimicrobial Peptide ‘Mastoparan’ and Evaluation of its Activity on Staphylococcus aureus Isolated from Mastitic Milk

Rajkumar James Singh; Sameer Shrivastava; Sonal; Pallavi Shah; Purnima Gogoi; Saumya Srivastava; Shahid Hussain; Deepanker Bisht; Shantanu Kodape; Rajeshwar Kh; are

doi:https://doi.org/10.20546/ijcmas.2019.811.046

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Original Research Articles Volume : 8, Issue:11, November, 2019

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
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Int.J.Curr.Microbiol.App.Sci.2019.8(11): 368-374

DOI: https://doi.org/10.20546/ijcmas.2019.811.046

Biophysical Characterization of Chemically Synthesized Antimicrobial Peptide ‘Mastoparan’ and Evaluation of its Activity on Staphylococcus aureus Isolated from Mastitic Milk

Rajkumar James Singh^*, Sameer Shrivastava, Sonal, Pallavi Shah, Purnima Gogoi, Saumya Srivastava, Shahid Hussain, Deepanker Bisht, Shantanu Kodape, Rajeshwar Khandare and Raj Kumar Singh

Department of Veterinary Biotechnology, ICAR- Indian Veterinary Research Institute, Izatnagar, Bareilly-243122- India

^*Corresponding author

Abstract:

A well-documented antimicrobial peptide, Mastoparan, initially isolated from the venom of wasp was chemically synthesized using solid phase peptide synthesis methodology. A total of 20 S. aureus isolates were isolated from milk samples. Antimicrobial sensitivity of these isolates against 9 (nine) conventional antibiotics, as well as, Mastoparan was studied. Majority of these isolates were resistant to many antibiotics. Mastoparan was observed to exhibit potent antimicrobial activity, even against some antibiotic-resistant isolates. Chloramphenicol was found to be most effective, whereas Ampicillin was least effective against S. aureus of milk origin.

Keywords: Antimicrobial peptide, Mastoparan, S. aureus, Antibiogram

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Rajkumar James Singh, Sameer Shrivastava, Sonal, Pallavi Shah, Purnima Gogoi, Saumya Srivastava, Shahid Hussain, Deepanker Bisht, Shantanu Kodape, Rajeshwar Khandare and Raj Kumar Singh. 2019. Biophysical Characterization of Chemically Synthesized Antimicrobial Peptide ‘Mastoparan’ and Evaluation of its Activity on Staphylococcus aureus Isolated from Mastitic Milk.Int.J.Curr.Microbiol.App.Sci. 8(11): 368-374. doi: https://doi.org/10.20546/ijcmas.2019.811.046

Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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Original Research Articles Volume : 8, Issue:11, November, 2019

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