International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 6, Issue:2, February, 2017

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(2): 1016-1023

QSAR and Anti-Depressant Studies of Some Novel Phenothiazine Derivatives
Nachiket S. Dighe1*, Nikhil N Kute1 and Deepak S. Musmade2
1Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy,Loni, MS, India-413736
2Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopergaon, MS, India-423601 
*Corresponding author

Antidepressants are the drugs used to treat depression thereby elevates mood and modifies the behavior. The main aims in the development of new antidepressants were greater efficacy, absence of side effects, lack of toxicity in over dose and earlier onset of action. In this study, a series of novel substituted phenothiazine was synthesized and evaluated for antidepressant activity by using or forced swim test (FST). Our synthetic route started from substituted aniline which was reacted with cyclohexanone. The later compound with sulfur powder and iodine led to the formation of the title compounds. Total 12 phenothiazine derivatives, A1 to A12 were tested for antidepressant activity by using or forced swim test (FST). All the synthesized compounds were subjected to antidepressant activity study on Sprague-Dawley rats by despair swim test. Imipramine was used as standard control. The results showed that all the compounds showed antidepressant activity. Among them two compounds, A3 and A6 showed significant antidepressant activity comparing with standard control imipramine.

Keywords: Antidepressant, Phenothiazine, QSAR, Sprague-Dawley Rats.

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How to cite this article:

Nachiket S. Dighe, Nikhil N Kute, Deepak S. Musmade. 2017. QSAR and Anti-Depressant Studies of Some Novel Phenothiazine Derivatives.Int.J.Curr.Microbiol.App.Sci. 6(2): 1016-1023. doi:
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