National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The use of Heliotropium indicum for the treatment of various conditions has been demonstrated by many précedants works. The aim of this present study was to demonstrate the hypotensive potential of this plant. Starting from an animal model, we were able to show that this aqueous extract at doses ranging between 3.51x10-3 and 3.75x10-2 g/kg bw, induced a sustained hypotension (dose-dependent) similar to that caused by acetylcholine (Ach) at doses ranging from 5.6x10-7 g/kg body weight and 5.5x10-4 g/kg body weight in rabbits.The study of the interaction between Adrenaline (Adr), a hypertensive reference molecule to 2.5x10-5 g/kg bw and aqueous extract of Heliotropium indicum (AEH) showed that the extract has significantly reduced the hypertension induced by Adr.These results indicated that the aqueous Heliotropium indicum extract had a hypotensive potential. The traditional use of this plant to treat arterial hypertension was justified.
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