International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 8, Issue:6, June, 2019

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(6): 1971-1975

Studies on the Effect of Bacteriophage Lysate of Pasteurella multocida on Serum Protein Levels in Rabbits
Yanglem Pushpa and Hari Mohan Saxena*
Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU), Ludhiana 141004 Punjab, India
*Corresponding author

The study was undertaken to evaluate the protein levels in rabbits affected by a lysate vaccine developed from Pasteurella multocida grown under iron-restricted conditions and lysed by a bacteriophage. Serum proteins include immunoglobulins and complement which mediate humoral immune response and an assessment of protein levels can be of clinical relevance being an indicator of humoral immune response. Two groups of rabbits were immunized with lysate vaccine (LV) and conventional alum precipitated killed HS vaccine (CV) and blood was collected at various days post – immunization (DPI). The serum protein concentration in lysate vaccinated rabbits (2.74 + 1.436) was significantly higher (p<0.05) than the conventional vaccinated rabbits (0.73 + 0.230) at 30 DPI. The increased total protein could be due to increase in various components like the acute phase proteins, immunoglobulins, lymphokines, mediators of inflammation and complement activation because of the antigenic stimulus provided by the phage lysate.

Keywords: Hemorrhagic septicemia, Pasteurella multocida, Bacteriophage, Phage lysate, Vaccine, Host response

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How to cite this article:

Yanglem Pushpa and Hari Mohan Saxena. 2019. Studies on the Effect of Bacteriophage Lysate of Pasteurella multocida on Serum Protein Levels in Rabbits.Int.J.Curr.Microbiol.App.Sci. 8(6): 1971-1975. doi:
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