National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The study was undertaken to evaluate the protein levels in rabbits affected by a lysate vaccine developed from Pasteurella multocida grown under iron-restricted conditions and lysed by a bacteriophage. Serum proteins include immunoglobulins and complement which mediate humoral immune response and an assessment of protein levels can be of clinical relevance being an indicator of humoral immune response. Two groups of rabbits were immunized with lysate vaccine (LV) and conventional alum precipitated killed HS vaccine (CV) and blood was collected at various days post – immunization (DPI). The serum protein concentration in lysate vaccinated rabbits (2.74 + 1.436) was significantly higher (p<0.05) than the conventional vaccinated rabbits (0.73 + 0.230) at 30 DPI. The increased total protein could be due to increase in various components like the acute phase proteins, immunoglobulins, lymphokines, mediators of inflammation and complement activation because of the antigenic stimulus provided by the phage lysate.
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