International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 8, Issue:6, June, 2019

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(6): 1308-1315

A Study of Scrub Typhus, Its Various Clinical Presentation and Antigenic Types Detected by IFA
S.R. Sujatha* and S. Deepa
Department of Microbiology, Mysore Medical College & research Institute Mysore, Karnataka, India
*Corresponding author

Scrub typhus is a bacterial zoonosis caused by Orientia tsutsugamushi. Timely diagnosis is necessary as the disease presents with varied signs, symptoms and may progresses to multiorgan dysfunction syndrome. Scrub typhus shows wide antigenic variation, one of the methods for its detection is IFA. There is scarcity of data regarding antigenic variations of Orientia tsutsugamushi which is of importance in our country. About 100 serum samples were collected from patients who had fever for > 7days (excluding other causes of fever). IFA detecting IgM antibodies to Orientia tsutsugamushi was done. Among 100 samples, 27 were positive by IFA. Common symptoms were abdominal pain (81.48%), vomiting (77.7%), myalgia (70.07%). O/E patients showed hepatomegaly (70.37%), lymphadenopathy (66. 6%), splenomegaly (51. 8%) and thrombocytopenia (77.77%) and Anaemia in (44.4 %) patients. Raised SGOT (81. 48%), SGPT (77.77%) with varied LFT was observed. Common Antigenic type was Gilliam (37. 03%), Karp (18.51%). Diagnosis of Scrub typhus is a challenge as it presents with various signs and symptoms. Antigenic variation of Orientia tsusugamushi will help in knowing a circulating strain which can be of use for a sensitive point of care test.

Keywords: Scrub typhus, IFA, Orientia tsutsugamushi

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How to cite this article:

Sujatha, S.R. and Deepa, S. 2019. A Study of Scrub Typhus, Its Various Clinical Presentation and Antigenic Types Detected by IFA.Int.J.Curr.Microbiol.App.Sci. 8(6): 1308-1315. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.