National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Treatment of castration-resistant prostate cancer (CRPC) patients with androgen deprivation therapy puts prostate cancer in remission while treatment with already available drugs in market including abirater one help in controlling advanced prostate cancers for sometime though fail to respond, evolve resistance mechanisms, and undergo genetic deregulations later on with poor patient survival rate and no cure. Also, if present trends of increasing life expectancy continue, given the current age-specific incidence, mortality rates of prostate cancer, this disease will become a far greater health problem worldwide in future. For this reason, addressing the curative treatment strategies for prostate cancer was the focal theme of our investigation. Our emphasis was on the extracts from medicinal plants of Kashmir Valley, which we collected from different floristically rich regions of Valley including Leh-Ladakh, Gurez, Dachigam National Sanctuary, Jawahar Lal Nehru Memorial Botanical Garden, Medicinal Plants Emporium Srinagar, Faculty of Forestry, SKUAST-K, Kangan and local nurseries in Srinagar area. In this study, we screened library of 372 extracts from collected medicinal plants (52) for their antiproliferative and anti-invasive efficacy through colony forming units and wound healing assays, which led to the identification of leaf extract of Podophyllum hexandrum as inhibitor molecule. Wound healing assay revealed that in presence of this extract, cancer cells show inhibition of cell movement, thus showing detrimental effect on invasiveness of C4-2 cells. CFU assay depicted inhibition of cellular proliferation and reduced colony forming units in C4-2, LnCaP and PC3 cells with increasing concentrations of this extract. Potential of this extract as a lead compound for the development of new treatment options for CRPC, including those resistant to enzalutamide, abiraterone and other anti-androgens could be explored through future studies. Also, different extracts of this plant will act as tool for evaluation of wide range of biological activities.
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