International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 8, Issue:4, April, 2019

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 2649-2667

Diuretic Activity of the Aqueous Extract Leaves of Crassocephalum crepidioides (Asteraceae) in Rats
Ntchapda Fidèle1*, Talla Ernest Rodrigue1, Bonabe Christian1, Kemeta Azambou David Romain1 and Talla Emmanuel2
1Department of Biological Sciences
2Department of Chemistry, Faculty of Science, University of Ngaoundéré, Cameroon, Po Box 454
*Corresponding author

Crassocephalum crepidioides is a medicinal plant used in west and central Africa, not only as leguminous crop, but also to treat high blood pressure in particular. The objective of this work was to evaluate the diuretic activity of aqueous leaves extract of C. crepidioides in the treatment of high blood pressure as claimed by traditional healers. Rats both male and female were used to evaluate the diuretic activity. C. crepidioides was administered to rats at 25, 50, 75, 100 and 125mg/kg. The volume of urine was measured after 3, 6, 12 and 24h following there administration of the aqueous extract. The two positive control groups received Furosemide and Hydrochlorothiazide amiloride respectively, whereas the negative control group received distilled water (1ml/100g of body weight). The urinary and blood concentrations of creatinine, urea, ALAT, ASAT and electrolytes (Na+, k+, Cl-) were evaluated using a spectrophotometer. The significant increase of diuresis was accompanied by that of electrolytes excretion (Na+, k+, Cl-), food and water consumption, creatinine and urea excretions. The increase in elimination of Na+, k+, Cl- induced by the extract provoked the alkalinization of urine. In the blood, a significant increase in the rates of electrolyte and urea, as well as a decrease in transaminase rate was noticed. However, no significant change was observed as far as the body weight and temperature, the pH of urine and the rate of creatinine serous in the animals treated with the aqueous extract of C. crepidioides. This work strongly indicated that C. crepidioides possesses a diuretic activity thus justifies its utilization by traditional healers for the cure of high blood pressure.

Keywords: Crassocephalum crepidioides, Diuretic and saluretic activities, Urinary volume, Urinary pH, Electrolytes

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How to cite this article:

Ntchapda Fidèle, Talla Ernest Rodrigue, Bonabe Christian, Kemeta Azambou David Romain and Talla Emmanuel. 2019. Diuretic Activity of the Aqueous Extract Leaves of Crassocephalum crepidioides (Asteraceae) in Rats.Int.J.Curr.Microbiol.App.Sci. 8(4): 2649-2667. doi:
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