International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2022 - IJCMAS--ICV 2022: 95.28 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020] For more details click here

Login as a Reviewer

See Guidelines to Authors
Current Issues
Download Publication Certificate

Original Research Articles                      Volume : 8, Issue:4, April, 2019

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 2624-2630

Vasorelaxant Effect of Heteratisine and 6–O–Benzoyl Heteratisine on Functional Activity of Rat Aorta Smooth Muscle Cells
Bakieva Sh. Muazzam1*, Zaynabiddinov E. Anvar1, Usmanov B. Pulat2 and Esimbetov T. Adilbay3
1Ministry of Higher and Secondary Special Education of the Republic of Uzbekistan,
Namangan State University, Republic of Uzbekistan
2Institute of Biophysics and Biochemistry at the National University of Uzbekistan, Republic of Uzbekistan
3Karakalpak State University named after Berdakh, Republic of Karakalpakstan
*Corresponding author

The effect of geteratisin (3–200 micromol/L) and 6–O–benzoylgeteratisin (10–250 micromol/L) on the contractile activity of the rat aorta smooth muscle cells (SMC) was studied. Isometric tension forces were recorded using a force transducer FT–03 (Grass Instrument Co., USA). In the experiments it was revealed that vasorelaxant effect of heteratisine is mainly associated with the blockade of Ca2+L–channel, receptor–operated Ca2+–channels (ROCC), and store–operated Ca2+–channels (SOCC). Vasorelaxant effect of 6–O–benzoyl heteratisine, which differs from heteratisine with the location of the benzoyl group in C(6)–position, is associated not only with the Ca2+L–channel blockade and SOCC/ROCC and the activation of the NO/cGC/cGMP/PKG cascade reaction.

Keywords: Heteratisine, 6–O–benzoyl heteratisine, Isolated rat aorta, Vasorelaxant effect, Са2+L–channels, NO–synthase, NO/GC/cGMP/ PKG

Download this article as Download

How to cite this article:

Bakieva Sh. Muazzam, Zaynabiddinov E. Anvar, Usmanov B. Pulat and Esimbetov T. Adilbay. 2019. Vasorelaxant Effect of Heteratisine and 6–O–Benzoyl Heteratisine on Functional Activity of Rat Aorta Smooth Muscle Cells.Int.J.Curr.Microbiol.App.Sci. 8(4): 2624-2630. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.