National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The effect of geteratisin (3–200 micromol/L) and 6–O–benzoylgeteratisin (10–250 micromol/L) on the contractile activity of the rat aorta smooth muscle cells (SMC) was studied. Isometric tension forces were recorded using a force transducer FT–03 (Grass Instrument Co., USA). In the experiments it was revealed that vasorelaxant effect of heteratisine is mainly associated with the blockade of Ca2+L–channel, receptor–operated Ca2+–channels (ROCC), and store–operated Ca2+–channels (SOCC). Vasorelaxant effect of 6–O–benzoyl heteratisine, which differs from heteratisine with the location of the benzoyl group in C(6)–position, is associated not only with the Ca2+L–channel blockade and SOCC/ROCC and the activation of the NO/cGC/cGMP/PKG cascade reaction.
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