A field experiment was undertaken to assess the bio-efficacy of post emergence herbicides against weed control in soybean. The predominant weed species in experimental field were Dinebra retroflexa, Echinocloa colona, Cyperus rotundus Lindernia ciliate and Mullogo pentaphylla. The maximum suppression of all the weed density, weed biomass and highest weed control efficiency vis-à-vis crop yield were obtained where twice hand weeding done at 20 and 40 days after sowing and closely followed by the treatment with Imazethapyr+Propaquizafop 75.0+62.5 g/ha, Imazethapyr alone at 100 g/ha and Imazethapyr+Bentazone 75.0+75 g/ha. Whereas weedy check treatment produced lowest yield of soybean among all the treatment. Highest weed index occurred in weedy check plots where weeds were not controlled throughout the crop season, among all herbicidal treatment lowest weed index falls in combination of Imazethapyr + Propaquizafop 75+62.5 g/ha.

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