National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Paracetamol induced hepatotoxicity is a common model for accessing the hepatoprotective nature of new molecules. This study was conducted to evaluate the potential of aqueous extract of Gyrocarpus asiaticus on paracetamol induced hepatotoxicity in zebra fish. Fish were challenged with 20mM concentration of paracetamol followed by treatment with aqueous extract of Gyrocarpus asiaticus. Serum was evaluated for alanine transferase (ALT) concentration and liver samples were collected for histopathological analysis. Result of this study showed that, there was marked elevation of ALT in induced group and compare to paracetamol induced toxicity group, Gyrocarpus asiaticus treated group has got marked reduction in ALT which also confirmed through histopathological analysis, where the treatment group showed normal morphological features. Hence further study can be done to elucidate the mechanism of action of Gyrocarpus asiaticus through molecular level to have a confirmation of hepatoprotective nature of this plant.
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