International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 8, Issue:4, April, 2019

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 1276-1282

Evaluation of C-Reactive Protein (CRP) in Early Diagnosis of Neonatal Septicemia
Ankita Nisarta1* and Rakesh Rajat2
1Department of Microbiology, GMERS Medical College, Himmatnagar, Gujarat, India
2Department of Microbiology, GMERS Medical College, Vadnagar, Gujarat, India
*Corresponding author

Neonatal septicemia constitutes a significant cause of neonatal mortality & morbidity in developing countries. It becomes essential to diagnose it as early as possible to reduce the mortality and treat with appropriate antibiotics. CRP is a sensitive & good inflammatory marker. Definite diagnosis of septicemia depends on positive blood culture, which takes around 48-72 hrs. Result of CRP test is available within an hour in tertiary care centers and remote areas, where there is no availability of well equipped laboratory setup for blood culture. 315 Neonates with suspected sepsis were included. Under aseptic precautions, Blood samples were collected in blood culture bottle & in Plain Vaccute. The CRP test was done by rapid slide latex agglutination method using the diagnostic kit (Tulip Diagnostics Ltd). Repeated Subcultures were performed. Identification of Organisms and Antibiotic sensitivity testing were done. Out of 315 cases, 180 (57%) had positive CRP and 135(43%) cases had positive blood culture. The Most common organism isolated were Gram negative organisms (65% ) like Klebsiella 56(41%) followed by Pseudomonas 19(14%), E. coli 11(8%), and Gram positive organisms (35%) like CONS 39(29%), Staphylococcus aureus 08(6%) . Estimation of CRP is easy to perform, rapid. It can use as inflammatory marker in early diagnosis of neonatal septicemia which will help to prevent severe and life threatening complications.

Keywords: CRP, Neonatal septicemia, Blood culture

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How to cite this article:

Ankita Nisarta and Rakesh Rajat. 2019. Evaluation of C-Reactive Protein (CRP) in Early Diagnosis of Neonatal Septicemia.Int.J.Curr.Microbiol.App.Sci. 8(4): 1276-1282. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.