International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:12, December, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(12): 897-902

The Relationship between Staphylococcus aureus Infection and Some Asthma Markers As (IL – 4, IL – 10, IFN γ, IgE and FOXP3) in Asthmatic Patients
Hamadi Aabttan Al-Hilali* and Mohammed Mousa Atta
Department of Microbiology, College of Medicine/Al-Qadissyia University, Iraq
*Corresponding author

The history of studies on the role of bacterial antigens for asthma go back to about 100 years ag. Since then, numerous researches have long been interested in the roles of bacteria particularly Staphylococcus aureus (S. aureus), in the pathogenesis of asthma but with controversy. It is just until recently that their significant association has come into the spotlight. In this study (for first time in Iraq ) we taking 100 asthmatic patients and 100  apparent  healthy control , the result of ELISA and  ASO-PCR and   RT - PCR  found there was significant relationship between Staphylococcal nasal infection with IFNγ polymorphism  also found IL-4 , total -  IgE and  IFNγ  were increased while IL- 10 and FOXP3 were decreased ,  that number of positive cases with S. aureus infection and nasal polyp had pneumonia and that corresponding with a recent advances in metagenomics technologies that proved the S. aureus bacteria not only colonize in the upper airways and skin but may be extend to lower airways particularly in the subjects with asthma. Also in the present study found that the eosinophil count is higher (675±480.2/cmm) in asthmatic patients carrier to S. aureus  than non carrier patients (450.1±145). To determine the relationship between asthma and nasal Staphylococcal infection. (100) one hundred asthmatic patients from Hilla specialized center for allergy with 100 apparently healthy age and sex matched subjects as controls. Blood and nasal swap samples were collected. Blood sample divided into two divisions heparinized part for DNA and RNA extraction and other non-heparinized part for serum isolation and Eosinophil counting. Nasal swap for bacterial culturing. After analysis of the results we found significant increasing in IFNγ, IgE and IL-4 but no effect on FOXP3  and IL-10 titers. Also significant increasing  in eosinophil count.  Nasal Staphylococcal infection had  significant relationship with asthma.

Keywords: Asthma. Staphylococcus aureus,Nasal Infection.

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Hamadi Aabttan Al-Hilali and Mohammed Mousa Atta. 2016. The Relationship between Staphylococcus aureus Infection and Some Asthma Markers As (IL – 4, IL – 10, IFN γ, IgE and FOXP3) in Asthmatic Patients.Int.J.Curr.Microbiol.App.Sci. 5(12): 897-902. doi:
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